Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
- 1 May 1985
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 315 (6015), 115-122
- https://doi.org/10.1038/315115a0
Abstract
Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of SV 40, large-T antigen was detected exclusively in the .beta.-cells of the endocrine pancrease of transgenic mice. The .alpha. and .delta.-cells normally found in the islets of Langerhans were rare and disordered. Well-vascularized .beta.-cell tumors arise in mice harboring and inheriting these hybrid oncogenes.Keywords
This publication has 39 references indexed in Scilit:
- Cell-specified expression of a selectable hybrid gene.Proceedings of the National Academy of Sciences of the United States of America, 1984
- Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genesNature, 1983
- Biosynthesis of rat insulins I and II: evidence for differential expression of the two genes.Proceedings of the National Academy of Sciences, 1982
- Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene.Proceedings of the National Academy of Sciences, 1981
- Genetic Variation in the Human Insulin GeneScience, 1980
- Sequence of the human insulin geneNature, 1980
- The structure and evolution of the two nonallelic rat preproinsulin genesCell, 1979
- Isolation and characterization of a cloned rat insulin geneCell, 1979
- A bacterial clone synthesizing proinsulin.Proceedings of the National Academy of Sciences, 1978
- Rat Insulin Genes: Construction of Plasmids Containing the Coding SequencesScience, 1977