Notch signaling: control of cell communication and cell fate
Top Cited Papers
- 1 March 2004
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 131 (5), 965-973
- https://doi.org/10.1242/dev.01074
Abstract
Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.Keywords
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