A chemical tool box defines mitotic and interphase roles for Mps1 kinase
Open Access
- 12 July 2010
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 190 (1), 21-24
- https://doi.org/10.1083/jcb.201006080
Abstract
In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase and mitotic inhibitors of Cdc20, and correction of faulty microtubule attachments.Keywords
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