Investigation on the biological activity of anthocyanins and polyphenols in blueberry
- 18 January 2021
- journal article
- research article
- Published by Wiley in Journal of Food Science
- Vol. 86 (2), 614-627
- https://doi.org/10.1111/1750-3841.15598
Abstract
Blueberry (Vaccinium spp.) is a fruit recognized in the world as healthy, and many of its active ingredients have important physiological functions. This study analyzed the antioxidant activity, antitumor activity, and immune function of anthocyanins and polyphenols extracted from blueberries. The crude extracts of anthocyanins and polyphenols were obtained from blueberries and then purified, and the extract exhibited excellent dose‐dependent antitumor activity and antioxidant activity in vivo and in vitro. The purified anthocyanins and polyphenol compounds showed higher antioxidant activity, whereas the crude extract had a better inhibitory effect on tumor proliferation than pure extract, and the blueberry anthocyanin and polyphenol crude product mixture showed a more powerful tumor suppressor, which may be the result of the synergistic effect of multiple compounds. The crude extracts were also more efficient at improving immune function, as reflected by measurements of change in body weight, thymus and spleen indices, macrophage phagocytosis, lymphocyte transformation capacity, superoxide dismutase activity, malondialdehyde content, and serum nitric oxide levels. These results indicate that blueberry anthocyanins and polyphenol extracts can improve immune function and reduce the metastasis and proliferation of cancer cells. This study reveals the functions of important active substances in blueberries and provides support for the development of functional health products and therapeutic drugs. Practical Application We compared the biological activity of crude and purified anthocyanins and polyphenol extracts from blueberries and tested their effects on improving immune function. This study contributes to a better understanding of the bioactivity of blueberry extracts and is valuable for further applications of blueberries in medicine.Keywords
Funding Information
- National Natural Science Foundation of China (31671899, 31871848)
This publication has 61 references indexed in Scilit:
- Blueberry Phytochemicals Inhibit Growth and Metastatic Potential of MDA-MB-231 Breast Cancer Cells through Modulation of the Phosphatidylinositol 3-Kinase PathwayCancer Research, 2010
- Baicalin suppresses lung carcinoma and lung metastasis by SOD mimic and HIF-1α inhibitionEuropean Journal of Pharmacology, 2010
- Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activityBehavioural Brain Research, 2009
- Chemoinhibitory Effect of Mulberry Anthocyanins on Melanoma Metastasis Involved in the Ras/PI3K PathwayJournal of Agricultural and Food Chemistry, 2008
- Antioxidant activity of protein extracts from heat-treated or thermally processed chickpeas and white beansFood Chemistry, 2007
- HPLC analysis of diverse grape and wine phenolics using direct injection and multidetection by DAD and fluorescenceJournal of Food Composition and Analysis, 2007
- Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide‐activated BV2 microgliaJournal of Neuroscience Research, 2007
- Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell lineCancer Letters, 2006
- Mechanism of the tumor suppressive effect of MnSOD overexpressionBiomedicine & Pharmacotherapy, 2005
- Tart cherry anthocyanins inhibit tumor development in ApcMin mice and reduce proliferation of human colon cancer cellsCancer Letters, 2003