Systemic Lupus Erythematosus: Presence in Human Serum of an Unusual Acid-Labile Leukocyte Interferon
- 23 April 1982
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4544), 429-431
- https://doi.org/10.1126/science.6176024
Abstract
A previously undescribed species of human leukocyte, or alpha, interferon is present in the serum of many patients with systemic lupus erythematosus. It was shown to be alpha-interferon by neutralization with specific antiserums, affinity column chromatography, and antiviral activity on bovine cells. However, 23 of 30 interferon samples tested were inactivated by incubation at pH 2, a characteristic of human "immune," or gamma, interferon. Multiple samples of interferon from the same patient had similar biological properties, but samples from different patients were not all identical, suggesting that several variants of this species of human alpha-interferon may exist.Keywords
This publication has 15 references indexed in Scilit:
- Molecular Weight of Human Gamma Interferon Is Similar to that of Other Human InterferonsScience, 1982
- Comparison of the Antiviral Activities of Various Cloned Human Interferon- Subtypes in Mammalian Cell CulturesJournal of General Virology, 1981
- DNA Sequence of Two Closely Linked Human Leukocyte Interferon GenesScience, 1981
- The structure of eight distinct cloned human leukocyte interferon cDNAsNature, 1981
- Human leukocyte interferon produced by E. coli is biologically activeNature, 1980
- The structure of one of the eight or more distinct chromosomal genes for human interferon-αNature, 1980
- At Least Three Human Type α Interferons: Structure of α2Science, 1980
- Interferon nomenclatureNature, 1980
- A monoclonal antibody for large-scale purification of human leukocyte interferonNature, 1980
- Immune Interferon in the Circulation of Patients with Autoimmune DiseaseNew England Journal of Medicine, 1979