Near-Full-Length Genome Sequences of a Novel HIV-1 Circulating Recombinant Form, CRF01_AE/B′/C (CRF78_cpx), in Yunnan, China
- 1 June 2016
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 32 (6), 601-606
- https://doi.org/10.1089/aid.2015.0351
Abstract
We report a novel HIV circulating recombinant form (CRF78_cpx) composed mainly of CRF01_AE with inserts from subtypes B and C identified from three epidemiologically unlinked individuals in Yunnan province, China. Two of the subjects are heterosexual men and one is a male intravenous drug user. Sequencing and analyzing the near-full-length genome of these three isolates (YNTC88, YNTC19, and YNTC35) revealed identical recombination breakpoints in all three viruses, but considerable genetic diversity between them, across the genomes, indicating that this is not a newly created CRF, only newly detected. CRF78_cpx differs from previously documented CRF01-AE/B′/C forms in its distinct backbone, inserted fragment size, and breakpoints, and is not related to other described recombinants in the region such as CRF07_BC or CRF65_cpx (also composed of CRF01_AE, B′, and C). Our present findings further enrich the diversity of the prevalent HIV-1 CRFs in Yunnan, which is considered as an epicenter of HIV-1 infections in China.Keywords
This publication has 16 references indexed in Scilit:
- CRF01_AE/B/C, a Novel Drug-Resistant HIV-1 Recombinant in Men Who Have Sex with Men in Beijing, ChinaAIDS Research and Human Retroviruses, 2015
- Near Full-Length Genome Identification of a Novel HIV-1 Recombinant Form (CRF01_AE/B′/C) Among Heterosexuals in Jilin, ChinaAIDS Research and Human Retroviruses, 2014
- Identification of a Novel HIV Type 1 Circulating Recombinant Form (CRF65_cpx) Composed of CRF01_AE and Subtypes B and C in Western Yunnan, ChinaAIDS Research and Human Retroviruses, 2014
- Recombination Form and Epidemiology of HIV-1 Unique Recombinant Strains Identified in Yunnan, ChinaPLOS ONE, 2012
- Surveys of Transmitted HIV Drug Resistance in 7 Geographic Regions in China, 2008–2009Clinical Infectious Diseases, 2012
- Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, ChinaTransfusion, 2009
- Dominance of HIV-1 Subtype CRF01_AE in Sexually Acquired Cases Leads to a New Epidemic in Yunnan Province of ChinaPLoS Medicine, 2006
- Molecular Epidemiology of the Heterosexual HIV-1 Transmission in Kunming, Yunnan Province of China Suggests Origin from the Local IDU EpidemicAIDS Research and Human Retroviruses, 2005
- A New Circulating Recombinant Form, CRF15_01B, Reinforces the Linkage between IDU and Heterosexual Epidemics in ThailandAIDS Research and Human Retroviruses, 2003
- Sequence Note: Cloning and Characterization of a Virtually Full-Length HIV Type 1 Genome from a Subtype B'-Thai Strain Representing the Most Prevalent B-Clade Isolate in ChinaAIDS Research and Human Retroviruses, 1998