CRF01_AE/B/C, a Novel Drug-Resistant HIV-1 Recombinant in Men Who Have Sex with Men in Beijing, China
- 1 July 2015
- journal article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 31 (7), 745-748
- https://doi.org/10.1089/aid.2015.0064
Abstract
We report a unique HIV-1 recombinant strain (URF) from an HIV-positive man who has sex with men (MSM) in Beijing, China. This virus genome has insertions and multiple drug-resistant mutations to both nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs), as well as a complex intersubtype recombinant structure with 11 breakpoints. Phylogenetic analysis of the near full-length genome (NFLG) shows that this URF is comprised of gene regions originating from three circulating viral strains: CRF01_AE, subtype B, and subtype C. The parental CRF01_AE regions of the recombinant cluster with a previously described cluster 4 sublineage of CRF01_AE. The B regions of the recombinant cluster within the B (United States-European origin) subtype and the three subtype C regions cluster with a strain detected in China in 1998. The detection and characterization of this complex drug-resistant URF indicate an ongoing generation of recombinant strains among MSM, and will help to provide insight into our understanding of the dynamics and complexity of the HIV-1 epidemic in China.Keywords
This publication has 18 references indexed in Scilit:
- Identification of 3 Distinct HIV-1 Founding Strains Responsible for Expanding Epidemic Among Men Who Have Sex With Men in 9 Chinese CitiesJAIDS Journal of Acquired Immune Deficiency Syndromes, 2013
- The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990sAIDS, 2013
- New Emerging Recombinant HIV-1 Strains and Close Transmission Linkage of HIV-1 Strains in the Chinese MSM Population Indicate a New Epidemic RiskPLOS ONE, 2013
- A Comprehensive Mapping of HIV-1 Genotypes in Various Risk Groups and Regions across China Based on a Nationwide Molecular Epidemiologic SurveyPLOS ONE, 2012
- The origin and diversity of the HIV-1 pandemicTrends in Molecular Medicine, 2012
- First Detection of a Novel HIV Type 1 CRF01_AE/07_BC Recombinant among an Epidemiologically Linked Cohort of IDUs in Jiangsu, ChinaAIDS Research and Human Retroviruses, 2009
- Characterization of HIV-1 subtypes and viral antiretroviral drug resistance in men who have sex with men in Beijing, ChinaAIDS, 2007
- MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0Molecular Biology and Evolution, 2007
- Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomesJournal of Virological Methods, 2006
- Characterization of Five Nearly Full-Length Genomes of Early HIV Type 1 Strains in Ruili City: Implications for the Genesis of CRF07_BC and CRF08_BC Circulating in ChinaAIDS Research and Human Retroviruses, 2005