Residual neurocognitive features of long‐term ecstasy users with minimal exposure to other drugs
- 26 October 2010
- Vol. 106 (4), 777-786
- https://doi.org/10.1111/j.1360-0443.2010.03252.x
Abstract
Aims In field studies assessing cognitive function in illicit ecstasy users, there are several frequent confounding factors that might plausibly bias the findings toward an overestimate of ecstasy‐induced neurocognitive toxicity. We designed an investigation seeking to minimize these possible sources of bias. Design We compared illicit ecstasy users and non‐users while (1) excluding individuals with significant life‐time exposure to other illicit drugs or alcohol; (2) requiring that all participants be members of the ‘rave’ subculture; and (3) testing all participants with breath, urine and hair samples at the time of evaluation to exclude possible surreptitious substance use. We compared groups with adjustment for age, gender, race/ethnicity, family‐of‐origin variables and childhood history of conduct disorder and attention deficit hyperactivity disorder. We provide significance levels without correction for multiple comparisons. Setting Field study. Participants Fifty‐two illicit ecstasy users and 59 non‐users, aged 18–45 years. Measurements Battery of 15 neuropsychological tests tapping a range of cognitive functions. Findings We found little evidence of decreased cognitive performance in ecstasy users, save for poorer strategic self‐regulation, possibly reflecting increased impulsivity. However, this finding might have reflected a pre‐morbid attribute of ecstasy users, rather than a residual neurotoxic effect of the drug. Conclusions In a study designed to minimize limitations found in many prior investigations, we failed to demonstrate marked residual cognitive effects in ecstasy users. This finding contrasts with many previous findings—including our own—and emphasizes the need for continued caution in interpreting field studies of cognitive function in illicit ecstasy users.This publication has 53 references indexed in Scilit:
- The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot studyJournal of Psychopharmacology, 2010
- Sleep Deprivation Differentially Impairs Cognitive Performance in Abstinent Methylenedioxymethamphetamine (“Ecstasy”) UsersJournal of Neuroscience, 2009
- Actions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neuronsPharmacology Biochemistry and Behavior, 2008
- Ecstasy use and higher-level cognitive functions: weak effects of ecstasy after control for potential confoundsPsychological Medicine, 2008
- Disrupted `reflection' impulsivity in cannabis users but not current or former ecstasy usersJournal of Psychopharmacology, 2008
- Specific effects of ecstasy and other illicit drugs on cognition in poly-substance usersPsychological Medicine, 2007
- Behavioral Control and Resiliency in the Onset of Alcohol and Illicit Drug Use: A Prospective Study From Preschool to AdolescenceChild Development, 2006
- A comparison of the Two One-Sided Tests Procedure and the Power Approach for assessing the equivalence of average bioavailabilityJournal of Pharmacokinetics and Biopharmaceutics, 1987
- Raven's Progressive Matrices (1938): More on norms, reliability, and validityJournal of Clinical Psychology, 1985
- The Purdue Pegboard: norms and studies of reliability and validity.Journal of Applied Psychology, 1948