Sleep Deprivation Differentially Impairs Cognitive Performance in Abstinent Methylenedioxymethamphetamine (“Ecstasy”) Users
Open Access
- 4 November 2009
- journal article
- research article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 29 (44), 14050-14056
- https://doi.org/10.1523/jneurosci.4654-09.2009
Abstract
Methylenedioxymethamphetamine (MDMA; “Ecstasy”) is a popular recreational drug and brain serotonin (5-HT) neurotoxin. Neuroimaging data indicate that some human MDMA users develop persistent deficits in brain 5-HT neuronal markers. Although the consequences of MDMA-induced 5-HT neurotoxicity are not fully understood, abstinent MDMA users have been found to have subtle cognitive deficits and altered sleep architecture. The present study sought to test the hypothesis that sleep disturbance plays a role in cognitive deficits in MDMA users. Nineteen abstinent MDMA users and 21 control subjects participated in a 5 d inpatient study in a clinical research unit. Baseline sleep quality was measured using the Pittsburgh Sleep Quality Inventory. Cognitive performance was tested three times daily using a computerized cognitive battery. On the third day of admission, subjects began a 40 h sleep deprivation period and continued cognitive testing using the same daily schedule. At baseline, MDMA users performed less accurately than controls on a task of working memory and more impulsively on four of the seven computerized tests. During sleep deprivation, MDMA users, but not controls, became increasingly impulsive, performing more rapidly at the expense of accuracy on tasks of working and short-term memory. Tests of mediation implicated baseline sleep disturbance in the cognitive decline seen during sleep deprivation. These findings are the first to demonstrate that memory problems in MDMA users may be related, at least in part, to sleep disturbance and suggest that cognitive deficits in MDMA users may become more prominent in situations associated with sleep deprivation.Keywords
This publication has 51 references indexed in Scilit:
- MDMA (ecstasy) use is associated with reduced BOLD signal change during semantic recognition in abstinent human polydrug users: a preliminary fMRI studyJournal of Psychopharmacology, 2009
- Low striatal serotonin transporter protein in a human polydrug MDMA (ecstasy) user: a case studyJournal of Psychopharmacology, 2008
- Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (±)3,4-methylenedioxymethamphetamine (“ecstasy”) users: relationship to cognitive performancePsychopharmacology, 2008
- Sleep Deprivation and Vigilant AttentionAnnals of the New York Academy of Sciences, 2008
- Specific effects of ecstasy and other illicit drugs on cognition in poly-substance usersPsychological Medicine, 2007
- The Effect of Catecholamine Depletion by Alpha-Methyl-Para-Tyrosine on Measures of Cognitive Performance and Sleep in Abstinent MDMA UsersNeuropsychopharmacology, 2007
- Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naïve ControlsNeuropsychopharmacology, 2005
- Confidence Limits for the Indirect Effect: Distribution of the Product and Resampling MethodsMultivariate Behavioral Research, 2004
- The effects of d-amphetamine on arousal, cognition, and mood after prolonged total sleep deprivation*1Neuropsychopharmacology, 1989
- Effects of sleep loss on sustained cognitive performance during a command and control simulationBehavior Research Methods, Instruments & Computers, 1985