Specific effects of ecstasy and other illicit drugs on cognition in poly-substance users
- 8 November 2007
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 38 (9), 1309-1317
- https://doi.org/10.1017/s0033291707002140
Abstract
A large number of studies, reviews and meta-analyses have reported cognitive deficits in ecstasy users. However most ecstasy users are polydrug users, and therefore it cannot be excluded that these deficits are (partly) the result of drugs other than ecstasy. The current study, part of the Netherlands XTC Toxicity (NeXT) study, investigates the specific sustained effects of ecstasy relative to amphetamine, cocaine and cannabis on the brain using neuropsychological examination. A stratified sample of 67 subjects with such a variation in type and amount of drug use was included that correlations between the consumption of the various drugs were relatively low allowing stepwise linear multiple regression analyses to differentiate between the effects of ecstasy and those of other substances. Subjects were assessed with neuropsychological tests measuring attention, working memory, verbal and visuospatial memory, and visuospatial ability. Ecstasy use [mean 327 (s.d.=364) tablets in lifetime] had a specific significant dose-related negative effect on verbal delayed recall after adjusting for the use of other drugs. These findings strongly suggest a specific sustained negative effect of ecstasy use on verbal memory. The clinical relevance is not immediately clear, because test performance generally remained within the normal range. However the magnitude of the effect is substantial (d>0.5) and long-term consequences cannot be excluded.Keywords
This publication has 34 references indexed in Scilit:
- Neuroimaging findings with MDMA/ecstasy: technical aspects, conceptual issues and future prospectsJournal of Psychopharmacology, 2006
- The confounding problem of polydrug use in recreational ecstasy/MDMA users: a brief overviewJournal of Psychopharmacology, 2006
- Neurotoxicity of methylenedioxyamphetamines (MDMA; ecstasy) in humans: how strong is the evidence for persistent brain damage?Addiction, 2006
- Ecstasy (MDMA) exposure and neuropsychological functioning: A polydrug perspectiveJournal of the International Neuropsychological Society, 2005
- Developments in the Epidemiology of Drug Use and Drug Use DisordersAmerican Journal of Psychiatry, 2005
- Auditory verbal learning in drug‐free Ecstasy polydrug usersHuman Psychopharmacology: Clinical and Experimental, 2001
- 5-HT system and cognitionNeuroscience & Biobehavioral Reviews, 1999
- Confabulation and the Control of RecollectionMemory, 1996
- Dementia: The Estimation of Premorbid Intelligence Levels Using the New Adult Reading TestCortex, 1978
- Mental Rotation of Three-Dimensional ObjectsScience, 1971