Catalytic Asymmetric C-N Bond Formation: Phosphine‐Catalyzed Intra‐ and Intermolecular γ‐Addition of Nitrogen Nucleophiles to Allenoates and Alkynoates
- 21 January 2013
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 52 (9), 2525-2528
- https://doi.org/10.1002/anie.201208957
Abstract
Pin the amine on the gamma: A new method has been developed for the γ‐addition of nitrogen nucleophiles to γ‐substituted alkynoates or allenoates through intra‐ and intermolecular processes that are catalyzed by spirophosphine 1 (see scheme). An asymmetric version of this reaction affords enantioenriched pyrrolidines, indolines, and γ‐amino‐α,β‐unsaturated carbonyl compounds.Keywords
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