The Yeast Nuclear Pore Complex
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Open Access
- 21 February 2000
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 148 (4), 635-652
- https://doi.org/10.1083/jcb.148.4.635
Abstract
An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic exchange requires a comprehensive inventory of the molecular components of the NPC and a knowledge of how each component contributes to the overall structure of this large molecular translocation machine. Therefore, we have taken a comprehensive approach to classify all components of the yeast NPC (nucleoporins). This involved identifying all the proteins present in a highly enriched NPC fraction, determining which of these proteins were nucleoporins, and localizing each nucleoporin within the NPC. Using these data, we present a map of the molecular architecture of the yeast NPC and provide evidence for a Brownian affinity gating mechanism for nucleocytoplasmic transport.Keywords
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