A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?
- 4 October 1996
- journal article
- review article
- Published by Elsevier BV in Cell
- Vol. 87 (1), 1-4
- https://doi.org/10.1016/s0092-8674(00)81315-x
Abstract
Macromolecular movement across the nuclear envelope is distinctly bidirectional. Proteins are targeted to and enter the nucleus at nuclear pore complexes (NPCs) in the nuclear envelope. The same NPCs promote passage of RNAs and proteins out of the nucleus. The precise orchestration of these movements is essential for proper gene expression, DNA replication, RNA processing, and viral maturation.Keywords
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