YEAST GENETICS TO DISSECT THE NUCLEAR PORE COMPLEX AND NUCLEOCYTOPLASMIC TRAFFICKING
- 1 December 1997
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 31 (1), 277-313
- https://doi.org/10.1146/annurev.genet.31.1.277
Abstract
▪ Abstract Eukaryotic cells evolved when their genetic information was packed into the cell nucleus. DNA replication and RNA biogenesis occur inside the nucleus while protein synthesis takes place in the cytoplasm. Bi-directional trafficking between these two compartments is mediated by a single supramolecular assembly, the nuclear pore complex. Nucleocytoplasmic transport is signal mediated, energy dependent, and requires, besides nuclear pore proteins (nucleoporins), a number of soluble transport factors. We review here our current knowledge on the role of nucleoporins, and on the mechanism of nucleocytoplasmic transport, with emphasis on the yeast Saccharomyces cerevisiae.Keywords
This publication has 83 references indexed in Scilit:
- A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?Cell, 1996
- The Nuclear Transport Factor Karyopherin β Binds Stoichiometrically to Ran-GTP and Inhibits the Ran GTPase Activating ProteinPublished by Elsevier BV ,1996
- Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteinsCell, 1995
- A Ran-binding motif in nuclear pore proteinsTrends in Cell Biology, 1995
- Nuclear export of proteins: The role of nuclear retentionCell, 1993
- Export of mRNA from microinjected nuclei of Xenopus laevis oocytes.The Journal of cell biology, 1992
- Shuttling of pre-mRNA binding proteins between nucleus and cytoplasmNature, 1992
- Nuclear protein localizationBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1991
- An N-ethylmaleimide-sensitive cytosolic factor necessary for nuclear protein import: requirement in signal-mediated binding to the nuclear pore.The Journal of cell biology, 1990
- Yeast nuclear envelope proteins cross react with an antibody against mammalian pore complex proteins.The Journal of cell biology, 1989