The biosynthesis of secretory component and its role in the transepithelial transport of IgA dimer
- 31 January 1985
- journal article
- review article
- Published by Elsevier BV in Immunology Today
- Vol. 6 (1), 17-20
- https://doi.org/10.1016/0167-5699(85)90163-x
Abstract
How animals protect their mucosal surfaces from environmental pathogens has been of much recent interest. Elucidation of the defence mechanisms involved led to the concept of a common mucosal immune system, characterized by an intimate relationship between mucosal epithelia and migrating populations of IgA-producing B cells1. However, in order to protect mucosal surfaces fom environmental antigens the dimeric IgA antibodies must somehow be transported across the mucous or exocrine gland epithelia and released into the external secretions. In this article R. Solari and J.-P. Kraehenbuhl show how the secretory component may facilitate this movement and also discuss its possible biosynthesis and processing.Keywords
This publication has 20 references indexed in Scilit:
- Intracellular receptor sorting during endocytosis: Comparative immunoelectron microscopy of multiple receptors in rat liverCell, 1984
- Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver.The Journal of cell biology, 1984
- Shift of equilibrium density induced by 3,3'-diaminobenzidine cytochemistry: a new procedure for the analysis and purification of peroxidase-containing organelles.The Journal of cell biology, 1984
- The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domainsNature, 1984
- Biosynthesis of the iga antibody receptor: A model for the transepithelial sorting of a membrane glycoproteinCell, 1984
- Evidence for a Vesicular Transport Mechanism in Hepatocytes for Biliary Secretion of Immunoglobulin AScience, 1980
- Movement of endocytic shuttle vesicles from the sinusoidal to the bile canalicular face of hepatocytes does not depend on occupation of receptor sitesFEBS Letters, 1980
- Synthesis of Secretory Component by Human Colon Cancer CellsScandinavian Journal of Immunology, 1976
- Structure and Function of Immunoglobulin A (Part 1 of 3)Published by S. Karger AG ,1972
- PEYER'S PATCHES: AN ENRICHED SOURCE OF PRECURSORS FOR IGA-PRODUCING IMMUNOCYTES IN THE RABBITThe Journal of Experimental Medicine, 1971