Biochemical and physiological effects of S-32–468, a beta-adrenoceptor antagonist with possible oculoselectivity
- 1 January 1985
- journal article
- research article
- Published by Informa UK Limited in Current Eye Research
- Vol. 4 (3), 191-197
- https://doi.org/10.3109/02713688509000850
Abstract
S-32-468, a recently synthesized aryloxymethyl beta-adrenoceptor antagonist, was tested for its ability to inhibit activation of isoproterenol-stimulated adenylate cyclase activity in rabbit and human ciliary process, heart and lung. In both species, S-32-468 was a potent inhibitor of ocular beta-adrenoceptors, with a 9-12 fold selectivity over inhibition of beta-adrenoceptors in cardiac tissue. When applied topically, S-32-468 was more effective than timolol in decreasing intraocular pressure in normal albino rabbits.Keywords
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