Adrenergic regulation of intraocular pressure: identification of beta 2-adrenergic-stimulated adenylate cyclase in ciliary process epithelium.
- 1 December 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 77 (12), 7420-7424
- https://doi.org/10.1073/pnas.77.12.7420
Abstract
To determine the site and possible mechanism of action of adrenergic agents in regulating intraocular pressure, .beta.-adrenergic receptors associated with adenylate cyclase in various ocular tissues involved in secretion and reabsorption of aqueous humor were identified, located and characterized. The ciliary process epithelium was enriched in an adenylate cyclase with pharmacological characteristics indicative of a predominance of .beta.2-adrenergic receptors. The adrenergic nervous system may regulate aqueous humor production through a direct effect on secretion. The potential development of drugs to control increased intraocular pressure in glaucoma patients is relevant.This publication has 21 references indexed in Scilit:
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