Reactive oxygen species, cell signaling, and cell injury
Top Cited Papers
- 1 May 2000
- journal article
- review article
- Published by Elsevier BV in Free Radical Biology & Medicine
- Vol. 28 (10), 1456-1462
- https://doi.org/10.1016/s0891-5849(00)00252-5
Abstract
Oxidative stress has traditionally been viewed as a stochastic process of cell damage resulting from aerobic metabolism, and antioxidants have been viewed simply as free radical scavengers. Only recently has it been recognized that reactive oxygen species (ROS) are widely used as second messengers to propagate proinflammatory or growth-stimulatory signals. With this knowledge has come the corollary realization that oxidative stress and chronic inflammation are related, perhaps inseparable phenomena. New pharmacological strategies aimed at supplementing antioxidant defense systems while antagonizing redox-sensitive signal transduction may allow improved clinical management of chronic inflammatory or degenerative conditions, including Alzheimer’s disease. Introduction of antioxidant therapies into mainstream medicine is possible and promising, but will require significant advances in basic cell biology, pharmacology, and clinical bioanalysis.Keywords
This publication has 54 references indexed in Scilit:
- Differential effects of α- and γ-tocopherol on low-density lipoprotein oxidation, superoxide activity, platelet aggregation and arterial thrombogenesisJournal of the American College of Cardiology, 1999
- Interaction of α‐Phenyl‐N‐tert‐Butyl Nitrone and Alternative Electron Acceptors with Complex I Indicates a Substrate Reduction Site Upstream from the Rotenone Binding SiteJournal of Neurochemistry, 1998
- Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox RegulationBiochemistry, 1998
- Epidermal Growth Factor (EGF)-induced Generation of Hydrogen PeroxidePublished by Elsevier BV ,1997
- Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal TransductionScience, 1995
- Breath ethane generation during clinical total body irradiation as a marker of oxygen-free-radical-mediated lipid peroxidation: A case studyFree Radical Biology & Medicine, 1994
- The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and AscorbateArchives of Biochemistry and Biophysics, 1993
- Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)Free Radical Research Communications, 1992
- The role of 8-hydroxyguanine in carcinogenesisCarcinogenesis: Integrative Cancer Research, 1990
- Free Radicals in Biological MaterialsNature, 1954