The in vitro and in vivo neuroprotective activity of sodium comenate in stress

Abstract

This paper reports an analysis of the effects of sodium comenate on neurite growth from spinal ganglia under the conditions of hydrogen peroxide-induced oxidative stress and on the glutathione antioxidant system in the brain of mice exposed to immobilization stress. It has been demonstrated that sodium comenate at the concentrations of 0.1–0.001 mM stimulates the growth of neurites from spinal ganglia exposed to oxidative stress. The most profound stimulatory effect was observed with 0.001 mM sodium comenate. The administration of sodium comenate at doses of 1, 2, and 4 mg/kg contributed to the maintenance of the GSH content and glutathione peroxidase and glutathione reductase activities at the physiologically normal state level under stress conditions. The results of the study of neurotrophic and antioxidant effects of sodium comenate in oxidative stress suggest that this compound is a highly efficient neuroprotector.