Neuroprotective Effect of Potassium Comenate Against Glutamate Toxicity on the Model of Cultured Rat Cerebellar Neurons
- 19 November 2014
- journal article
- Published by Springer Science and Business Media LLC in Bulletin of Experimental Biology and Medicine
- Vol. 158 (1), 49-52
- https://doi.org/10.1007/s10517-014-2689-4
Abstract
The study demonstrated neuroprotective action of novel chemical agent, potassium salt of comenic acid, against the glutamate-induced cytotoxicity on the model of cultured cerebral neurons. Potassium comenate (0.001-1.0 mM) significantly decreased the rate of glutamateinduced neuronal death. The highest viability of the cultured neurons during postglutamate time was observed when potassium comenate was applied in a concentration of 0.1 mM.Keywords
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