Antioxidant activity of three extracts of Morus nigra
- 26 May 2004
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 18 (5), 365-369
- https://doi.org/10.1002/ptr.1400
Abstract
The antioxidant effect of three different extracts of Morus nigra fruit (fruit juice, hydroalcoholic and polyphenolic) on haemoglobin glycosylation, peroxidative damage to human erythrocytes, liver hepatooytes of rats and human low‐density lipoprotein (LDL) were studied. The results show that all three extracts inhibited haemoglobin glycosylation induced by glucose to differing degrees. The haemolysis of human erythrocytes induced by hydrogen peroxide was also inhibited. The production of malondialdehyde (MDA) during peroxidative damage to plasma membranes of isolated rat hepatocytes induced by tert‐butyl hydroperoxide (tBH) was also inhibited. Inhibition of lipid peroxidation of LDL induced by copper (II) ion was achieved during the study. The results suggest that Morus nigra fruit has a protective action against peroxidative damage to biomembranes and biomolecules. Copyright © 2004 John Wiley & Sons, Ltd.Keywords
This publication has 24 references indexed in Scilit:
- Antioxidant Vitamins and Coronary Heart DiseaseThe New England Journal of Medicine, 1993
- Quercetin prevents the cytotoxicity of oxidized LDL on lymphoid cell linesFree Radical Biology & Medicine, 1992
- Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in manThe Lancet, 1992
- Protective action of seven natural phenolic compounds against peroxidative damage to biomembranesBiochemical Pharmacology, 1992
- Role of oxidized low density lipoprotein in atherogenesis.JCI Insight, 1991
- Tert-Butyl Hydroperoxide-Induced Injury In Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude DrugsPlanta Medica, 1990
- Effects of flavonoids on nonenzymatic lipid peroxidation: Structure-activity relationshipBiochemical Medicine and Metabolic Biology, 1988
- Hydroxyl radical scavenging activity of flavonoidsPhytochemistry, 1987
- Antioxidants in relation to lipid peroxidationChemistry and Physics of Lipids, 1987
- Stability of flavonoid complexes of copper(II) and flavonoid antioxidant activityAnalytica Chimica Acta, 1976