Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation
Top Cited Papers
- 29 August 2013
- journal article
- Published by American Society of Hematology in Blood
- Vol. 122 (9), 1610-1620
- https://doi.org/10.1182/blood-2013-01-481457
Abstract
Key Points Pim2 expression is highly elevated in multiple myeloma and is required for multiple myeloma proliferation. Pim2 phosphorylates TSC2 and modulates mTOR-C1 activity to promote multiple myeloma cell proliferation.Keywords
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