Green Preparation Process, Characterization and Antitumor Effects of Doxorubicin–BSA–Dextran Nanoparticles
- 2 July 2010
- journal article
- research article
- Published by Wiley in Macromolecular Bioscience
- Vol. 10 (10), 1224-1234
- https://doi.org/10.1002/mabi.201000125
Abstract
In this report, we developed a simple and green process of simultaneous formation of doxorubicin-BSA-dextran nanoparticles in aqueous solution and high-effective encapsulation of doxorubicin. In the presence of BSA-dextran conjugates, which were produced by Maillard reaction, a binding of doxorubicin with BSA can suppress the self-aggregation of unprotonated doxorubicin. After a heat treatment, the gelation of BSA results in a formation of the nanoparticles and the doxorubicin was fixed inside the nanoparticles. The dextran shell makes the nanoparticles dispersible in solution. The nanoparticles have a spherical morphology and a hydrodynamic radius of about 90 nm. Importantly, the nanoparticles can significantly prolong the life of murine ascites hepatoma H22 tumor-bearing mice.Keywords
Funding Information
- National Natural Science Foundation of China (50673020)
- Science and Technology Committee of Shanghai Municipality (07DJ14004)
- National Basic Research Program of China (2009CB930400)
- State New Drug Innovation of China (2009ZX09310-003)
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