Stable and pH-Sensitive Nanogels Prepared by Self-Assembly of Chitosan and Ovalbumin
- 16 February 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 22 (6), 2754-2759
- https://doi.org/10.1021/la053158b
Abstract
Two natural macromolecules, chitosan and ovalbumin, were used to produce nanogels by a new, green, and convenient method. Chitosan and ovalbumin solutions were mixed; the pH of the resulting solution was adjusted; and the solution was successively stirred and heated. After that, ovalbumin gelled forming nanospheres. The chitosan chains are supposed to be partly trapped in the nanogel core upon heating because of the electrostatic attractions between chitosan and ovalbumin, while the rest of the chitosan chains should form the shell of the nanogels. The nanogels did not change the size distribution after long-time storage and did not dissociate in the pH range of 2−10.5. The dispersibility, size, and hydrophobicity/hydrophilicity of the nanogels are pH-dependent. The nanogels are good candidates for cosmetic and pharmaceutical applications.Keywords
This publication has 26 references indexed in Scilit:
- Preparation and Characterization of Chitosan-Based NanoparticlesBiomacromolecules, 2005
- Recent advances on chitosan-based micro- and nanoparticles in drug deliveryJournal of Controlled Release, 2004
- Protein–polysaccharide interactions: phase-ordering kinetics, thermodynamic and structural aspectsCurrent Opinion in Colloid & Interface Science, 2003
- Chitosan as Antimicrobial Agent: Applications and Mode of ActionBiomacromolecules, 2003
- Roles of Electrostatic Interaction and Polymer Structure in the Binding of β-Lactoglobulin to Anionic Polyelectrolytes: Measurement of Binding Constants by Frontal Analysis Continuous Capillary ElectrophoresisLangmuir, 2000
- Fluorescence and Conductivity Studies of Polyelectrolyte-Induced Aggregation of Alkyltrimethylammonium BromidesLangmuir, 1999
- Microspheres and nanoparticles used in ocular delivery systemsAdvanced Drug Delivery Reviews, 1995
- Recent advances in the understanding of egg white protein functionalityTrends in Food Science & Technology, 1995
- Regime transitions in fractions of cis-polyisopreneMacromolecules, 1987
- Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systemsJournal of the American Chemical Society, 1977