Drug Delivery Systems: Entering the Mainstream
Top Cited Papers
- 19 March 2004
- journal article
- special viewpoints
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 303 (5665), 1818-1822
- https://doi.org/10.1126/science.1095833
Abstract
Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.Keywords
This publication has 39 references indexed in Scilit:
- Small-scale systems for in vivo drug deliveryNature Biotechnology, 2003
- The dawning era of polymer therapeuticsNature Reviews Drug Discovery, 2003
- Myths concerning the use of cationic liposomes in vivoExpert Opinion on Biological Therapy, 2003
- Pharmacokinetics of Pegylated Liposomal DoxorubicinClinical Pharmacokinetics, 2003
- Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatinCancer Chemotherapy and Pharmacology, 2002
- ROLE OF COMPLEMENT ACTIVATION IN HYPERSENSITIVITY REACTIONS TO DOXIL AND HYNIC PEG LIPOSOMES: EXPERIMENTAL AND CLINICAL STUDIESJournal of Liposome Research, 2002
- Unbedenklichkeitsaspekte bei der Anwendung von pegyliertem liposomalem Doxorubicin bei KrebspatientenDrugs, 1997
- Effect of Transvascular Fluid Exchange on Pressure–Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow HeterogeneityMicrovascular Research, 1996
- Doxorubicin Encapsulated in Liposomes Containing Surface‐Bound Polyethylene Glycol: Pharmacokinetics, Tumor Localization, and Safety in Patients with AIDS‐Related Kaposi's SarcomaThe Journal of Clinical Pharmacology, 1996
- A retrospective clinical comparison between antifungal treatment with liposomal amphotericin B (AmBisome) and conventional amphotericin B in transplant recipientsMycoses, 1992