Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams
- 22 October 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 19 (44), 9688-9691
- https://doi.org/10.1039/d1ob01846a
Abstract
An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized γ-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.Funding Information
- Henan Agricultural University (30500739)
- National Natural Science Foundation of China (22001059)
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