Generation of Rhodium(I) Carbenes from Ynamides and Their Reactions with Alkynes and Alkenes
- 23 May 2013
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 135 (22), 8201-8204
- https://doi.org/10.1021/ja4047069
Abstract
Rh(I) carbenes were conveniently generated from readily available ynamides. These metal carbene intermediates could undergo metathesis with electron-rich or neutral alkynes to afford 2-oxopyrrolidines or be trapped by tethered alkenes to yield 3-azabicyclo[3.1.0]hexanes, a common skeleton in numerous bioactive pharmaceuticals. Although the scope of the former is limited, the latter reaction tolerates various substituted alkenes.This publication has 72 references indexed in Scilit:
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