Mediterranean Diet and Weight Loss: Meta-Analysis of Randomized Controlled Trials
- 1 February 2011
- journal article
- review article
- Published by Mary Ann Liebert Inc in Metabolic Syndrome and Related Disorders
- Vol. 9 (1), 1-12
- https://doi.org/10.1089/met.2010.0031
Abstract
Background: The epidemiological evidence supporting a causal link between Mediterranean diets and body weight is contrasting. We evaluated the effect of Mediterranean diets on body weight in randomized controlled trials (RCTs) using a meta-analysis. Methods: We searched English and non-English publications in PubMed, Embase, Scopus, and the Cochrane Central Register of Controlled Trials from inception to January, 2010. Two evaluators independently selected and reviewed eligible studies. Sixteen randomized controlled trials, with 19 arms and 3,436 participants (1,848 assigned to a Mediterranean diet and 1,588 assigned to a control diet) were included. Results: In a random-effects meta-analysis of all 19 arms, the Mediterranean diet group had a significant effect on weight [mean difference between Mediterranean diet and control diet, −1.75 kg; 95% confidence interval (CI), −2.86 to −0.64 kg] and body mass index (mean difference, −0.57 kg/m2, −0.93 to −0.21 kg/m2). The effect of Mediterranean diet on body weight was greater in association with energy restriction (mean difference, −3.88 kg, −6.54 to −1.21 kg), increased physical activity (−4.01 kg, −5.79 to −2.23 kg), and follow up longer than 6 months (−2.69 kg, −3.99 to −1.38 kg). No study reported significant weight gain with a Mediterranean diet. Conclusions: Mediterranean diet may be a useful tool to reduce body weight, especially when the Mediterranean diet is energy-restricted, associated with physical activity, and more than 6 months in length. Mediterranean diet does not cause weight gain, which removes the objection to its relatively high fat content. These results may be useful for helping people to lose weight.This publication has 35 references indexed in Scilit:
- Dietary fat intake and subsequent weight change in adults: results from the European Prospective Investigation into Cancer and Nutrition cohortsThe American Journal of Clinical Nutrition, 2009
- Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and CarbohydratesNew England Journal of Medicine, 2009
- Obesity and the Mediterranean diet: a systematic review of observational and intervention studiesObesity Reviews, 2008
- Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat DietNew England Journal of Medicine, 2008
- Comparison of Low-Fat Versus Mediterranean-Style Dietary Intervention After First Myocardial Infarction (from The Heart Institute of Spokane Diet Intervention and Evaluation Trial)†The American Journal of Cardiology, 2008
- Mediterranean diet and metabolic diseasesCurrent Opinion in Lipidology, 2008
- Mediterranean diet has no effect on markers of inflammation and metabolic risk factors in patients with coronary artery diseaseEuropean Journal of Clinical Nutrition, 2005
- Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic SyndromeJAMA, 2004
- Assessing the quality of reports of randomized clinical trials: Is blinding necessary?Controlled Clinical Trials, 1996