Risk of Cirrhosis and Primary Liver Cancer in Alpha1-Antitrypsin Deficiency

Abstract

Previous reports have suggested an association between homozygous α₁-antitrypsin deficiency, cirrhosis, and primary liver cancer. To assess the risk of these complications we conducted a retrospective study based on 17 autopsied cases of α₁-antitrypsin deficiency identified during the period 1963 to 1982 in the city of Malmö, Sweden. During the study period, autopsies were performed in 38,250, or 68.2 percent, of all patients in the city who died. From the homozygote frequency in the population, 21 of these were expected to have α₁-antitrypsin deficiency. The disease had been diagnosed in 20, and autopsies had been performed in 17 (1 child and 16 adults). Each autopsied case was matched with four controls selected from the same autopsy register, and the Mantel–Haenszel odds ratio (OR_mh) was calculated. The results indicated a strong relation between α₁-antitrypsin deficiency and cirrhosis (OR_mh = 7.8; 95 percent confidence limits, 2.4 to 24.7) and primary liver cancer (OR_mh = 20; 95 percent confidence limits, 3.5 to 114.3). When data were stratified according to sex, these associations were statistically significant only for male patients.