Alpha 1-antitrypsin levels and phenotypes and hepatitis B serology in liver cancer
Open Access
- 30 April 1984
- journal article
- research article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 49 (5), 567-570
- https://doi.org/10.1038/bjc.1984.90
Abstract
Serum levels of alpha 1-antitrypsin (alpha 1 AT) were measured by radial immunodiffusion and phenotypes were determined by electrofocusing in acrylamide gel in 39 patients with hepatocellular carcinoma (HCC) positive for serum hepatitis B surface antigen (HBsAg), 41 patients with HCC negative for serum HBsAg, and 160 age- and sex-matched hospital controls. There was no difference between the control series and either of the two HCC groups with respect to alpha 1 AT phenotype pattern, also, there was no evidence of association between HCC and either the M2 allele or any of the alpha 1 AT deficiency phenotypes. However, HCC cases negative for HBsAg had significantly higher serum alpha 1 AT values (mean 665 +/- 26 mg 100 ml-1) than HCC cases positive for HBsAg (mean 571 +/- 23 mg 100 ml-1), who in turn, had significantly higher alpha 1 AT values than hospital controls (mean 434 +/- 13 mg 100 ml-1). These results indicate that in Greece, as in other high HCC incidence countries, genetically determined alpha 1 AT deficiency is not aetiologically important, the increase of serum alpha 1 AT is an important correlate of HCC with possible aetiologic significance and diagnostic potential and HBsAg-positive HCC and HBsAg-negative HCC are manifest differently as well as being aetiologically distinct.Keywords
This publication has 18 references indexed in Scilit:
- Protease Inhibitors — A Precarious BalanceNew England Journal of Medicine, 1983
- [Alpha 1-antitrypsin deficiency and the liver (author's transl)].1982
- HEPATITIS-B VIRUS AND CIGARETTE-SMOKING - RISK-FACTORS FOR HEPATOCELLULAR-CARCINOMA IN HONG-KONG1982
- Does hepatitis B virus cause hepatocellular carcinoma?1982
- Smoking and Hepatitis B-Negative Primary Hepatocellular Carcinoma23JNCI Journal of the National Cancer Institute, 1980
- Preferential Transmission of the Z Deficient Allele of α 1 -AntitrypsinScience, 1979
- α1-Antitrypsine et tabac, UNE etude DE 1296 hommes sainsClinica Chimica Acta; International Journal of Clinical Chemistry, 1979
- Alpha-1-antitrypsin deficiency and hepatocellular carcinoma.Journal of Clinical Pathology, 1979
- HEPATITIS B AND PRIMARY HEPATOCELLULAR CARCINOMA IN A EUROPEAN POPULATIONThe Lancet, 1978
- Alpha1-Antitrypsin DeficiencyNew England Journal of Medicine, 1978