Cytotype Regulation by TelomericPElements inDrosophila melanogaster: Evidence for Involvement of an RNA Interference Gene
- 1 August 2007
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 176 (4), 1945-1955
- https://doi.org/10.1534/genetics.106.066746
Abstract
P elements inserted at the left telomere of the X chromosome evoke the P cytotype, a maternally inherited condition that regulates the P-element family in the Drosophila germline. This regulation is completely disrupted in stocks heterozygous for mutations in aubergine, a gene whose protein product is involved in RNA interference. However, cytotype is not disrupted in stocks heterozygous for mutations in two other RNAi genes, piwi and homeless (spindle-E), or in a stock heterozygous for a mutation in the chromatin protein gene Enhancer of zeste. aubergine mutations exert their effects in the female germline, where the P cytotype is normally established and through which it is maintained. These effects are transmitted maternally to offspring of both sexes independently of the mutations themselves. Lines derived from mutant aubergine stocks reestablish the P cytotype quickly, unlike lines derived from stocks heterozygous for a mutation in Suppressor of variegation 205, the gene that encodes the telomere-capping protein HP1. Cytotype regulation by telomeric P elements may be tied to a system that uses RNAi to regulate the activities of telomeric retrotransposons in Drosophila.Keywords
This publication has 27 references indexed in Scilit:
- Cytotype Regulation by TelomericPElements inDrosophila melanogaster: Interactions WithPElements From M′ StrainsGenetics, 2007
- Transcription of the singed-weak mutation of Drosophila melanogaster: elimination of P-element sequences by RNA splicing and repression of singed transcription in a P genetic backgroundMolecular Genetics and Genomics, 2007
- A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the GermlineScience, 2006
- Impairment of Cytotype Regulation of P-Element Activity in Drosophila melanogaster by Mutations in the Su(var)205 GeneGenetics, 2005
- aubergine mutations in Drosophila melanogaster impair P cytotype determination by telomeric P elements inserted in heterochromatin.Molecular Genetics and Genomics, 2004
- Heterochromatin Protein 1 Is Involved in Control of Telomere Elongation in Drosophila melanogasterMolecular and Cellular Biology, 2002
- Cytotype control of Drosophila P element transposition: The 66 kd protein is a repressor of transposase activityCell, 1990
- The accumulation of P-elements on the tip of theXchromosome in populations ofDrosophila melanogasterGenetics Research, 1989
- Hybrid dysgenesis inDrosophila melanogaster: rules of inheritance of female sterilityGenetics Research, 1979
- The estimation of mutation rates when premeiotic events are involvedEnvironmental Mutagenesis, 1979