Synthesis of Naphthopyrans via Formal (3+3)-Annulation of Propargylic (Aza)-para-Quinone Methides with Naphthols
- 29 September 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 85 (20), 13306-13316
- https://doi.org/10.1021/acs.joc.0c01791
Abstract
Herein, we report an efficient Brønsted acid-catalyzed formal (3+3)-annulation of (aza)-para-quinone methides generated in situ from propargylic alcohols with naphthol derivatives, which involves 1,8-conjugate addition/6-endo annulation process. This protocol provides an effective method for preparing important functionalized pyranocoumarins under mild conditions.Keywords
Funding Information
- Department of Education of Guangdong Province (2019KTSCX184)
- Jiangmen City Science and Technology Basic Research Project (2020030102050005285, 2020030102060005412)
- Project of Young Innovative Talents in Colleges and Universities in Guangdong Province (2018KQNCX263)
- COVID-19 Epidemic Prevention and Control Project of Wuyi University (2020FKZX01)
- Science Foundation for Young Teachers of Wuyi University (2019td02)
- Jiangmen Program for Innovative Research Team (2018630100180019806)
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