Total Synthesis of the Antibiotic Elansolid B1
- 7 January 2014
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 16 (2), 568-571
- https://doi.org/10.1021/ol403441c
Abstract
The antibiotic elansolid B1 was prepared by a convergent strategy that relied on a highly diastereoselective, biomimetic intramolecular Diels-Alder cycloaddition (IMDA) that furnished the tetrahydroindane unit. Other key features are a double Sonogashira cross-coupling and a substrate-controlled Yamamoto aldol reaction.Keywords
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