Uveodermatologic lymphoma in two young related Portuguese water dogs
- 12 January 2012
- journal article
- case report
- Published by Wiley in Veterinary Ophthalmology
- Vol. 15 (5), 345-350
- https://doi.org/10.1111/j.1463-5224.2011.00981.x
Abstract
Canine lymphoma (CL) is one of the most common forms of spontaneous canine neoplasia. Improved understanding of the genetic and environmental factors associated with CL may provide benefits for the study of non-Hodgkin's and Hodgkin's lymphoma in humans. Uveodermatologic lymphoma is reported in a single household of Portuguese water dog, and the etiology is discussed. A 1-year-old female intact Portuguese water dog was referred to the Ophthalmology Service of the Veterinary Teaching Hospital of the Autonomous University of Barcelona because of acute blepharospasm of the right eye in association with a multinodular dermatosis. Physical and ophthalmological examination and a complete diagnostic work-up, including skin and ocular histopathology and immunohistochemistry, were performed. Three months prior, in Galicia (Spain), 1200 km away from Barcelona, a male dog of the same litter showed very similar oculodermatological clinical signs and skin histopathology, and immunohistochemistry were obtained. The clinical diagnoses were anterior exudative uveitis, iridal masses, and secondary glaucoma. Histopathology and immunohistochemistry revealed a nonepitheliotropic lymphoma rich in B cell in dog 1 and rich in T cell in dog 2. It is proposed that an underlying genetic predisposition could have played a role in the development of lymphoma in these two young related dogs.Keywords
This publication has 30 references indexed in Scilit:
- Understanding the genetics of autoimmune disease: two loci that regulate late onset Addison's disease in Portuguese Water DogsInternational Journal of Immunogenetics, 2006
- Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable RiskCancer Research, 2005
- Unicentric extranodal lymphoma of the upper eyelid conjunctiva in a dogVeterinary Ophthalmology, 2005
- Infantile dilated cardiomyopathy in Portuguese water dogs: Correlation of the autosomal recessive trait with low plasma taurine at infancyAmino Acids, 2004
- Genomic hypomethylation in neoplastic cells from dogs with malignant lymphoproliferative disordersResearch in Veterinary Science, 2003
- {\rtf1\ansi\ansicpg1250\deff0\deflang1038\deflangfe1038\deftab708{\fonttbl{\f0\froman\fprq2\fcharset238{\*\fname Times New Roman;}Times New Roman CE;}} \viewkind4\uc1\pard\f0\fs24 N-ras mutation in a canine lymphoma: Short communication \par}Acta Veterinaria Hungarica, 2003
- Association Between Canine Malignant Lymphoma, Living in Industrial Areas, and Use of Chemicals by Dog OwnersJournal of Veterinary Internal Medicine, 2001
- Canine malignant lymphoma: A review and comparison with human non‐hodgkin's lymphomaVeterinary Quarterly, 1994
- Clustering in canine malignant lymphomaVeterinary Quarterly, 1994
- Cell-mediated and humoral immunity in dogs with spontaneous lymphosarcomaEuropean Journal of Cancer (1965), 1975