Unicentric extranodal lymphoma of the upper eyelid conjunctiva in a dog
- 11 January 2005
- journal article
- case report
- Published by Wiley in Veterinary Ophthalmology
- Vol. 8 (1), 67-70
- https://doi.org/10.1111/j.1463-5224.2005.04053.x
Abstract
A case of conjunctival lymphoma in a 4-year-old Siberian husky is reported. A large red mass protruding from the conjunctiva of the upper eyelid of the right eye was present. Irritation, blepharospasm and epiphora were revealed on initial ophthalmic examination. After anti-inflammatory treatment, surgery was performed. Histologically, the mass consisted of large polygonal cells with a high nucleus to cytoplasm ratio, moderate amounts of slightly eosinophilic cytoplasm, pleomorphic nuclei with vesicular chromatin and prominent multiple nucleoli. Mitotic figures were frequent. Approximately 70% of the neoplastic cells were CD3 positive and CD79alpha negative. On the basis of histologic and immunohistochemical findings, a diagnosis of intermediate-grade, diffuse large-cell lymphoma with T-cell immunophenotype was made. The surgical area healed uneventfully and, although chemotherapy was not received, after 12 months the dog exhibited no recurrence. To the authors' knowledge, this is the first report of unicentric extranodal conjunctival lymphoma in a dog.Keywords
This publication has 10 references indexed in Scilit:
- MALT lymphomasCurrent Treatment Options in Oncology, 2003
- Tumors of the ConjunctivaPublished by Wiley ,2002
- Primary lymphoma of the conjunctiva - a rare manifestation of indolent non-Hodgkin's lymphomaAnnals of Hematology, 2001
- Conjunctival lymphoid tumorsOphthalmology, 2001
- Progression of an Orbital T-cell Rich B-cell Lymphoma to a B-cell Lymphoma in a DogVeterinary Pathology, 2000
- Epitheliotropic lymphoma (mycosis fungoides) presenting as blepharoconjunctivitis in an Irish setterJournal of Small Animal Practice, 2000
- Prognostic factors for treatment of malignant lymphoma in dogsJournal of the American Veterinary Medical Association, 1994
- The Eye and EarPublished by Elsevier BV ,1993
- Phenotyping of canine lymphoma with monoclonal antibodies directed at cell surface antigens: Classification, morphology, clinical presentation and response to chemotherapyHematological Oncology, 1984
- National cancer institute sponsored study of classifications of non-hodgkin's lymphomas. Summary and description of a working formulation for clinical usageCancer, 1982