Cdc42 and Vesicle Trafficking in Polarized Cells
- 12 July 2010
- Vol. 11 (10), 1272-1279
- https://doi.org/10.1111/j.1600-0854.2010.01102.x
Abstract
Cdc42, a highly conserved small GTPase of the Rho family, acts as a molecular switch to modulate a wide range of signaling pathways. Vesicle trafficking and cell polarity are two processes Cdc42 is known to regulate. Although the trafficking and polarity machineries are each well understood, how they interact to cross-regulate each other in cell polarization is still a mystery. Cdc42 is an interesting candidate that may integrate these two networks within the cell. Here we review findings on the interplay between Cdc42 and trafficking in yeast, Caenorhabditis elegans, Drosophila and mammalian cell culture systems, and discuss recent advances in our understanding of the function of Cdc42 and two of its effectors, the WASp-Arp2/3 and Par complexes, in regulating polarized traffic. Work in yeast suggests that the polarized distribution of Cdc42, which acts here as a key polarity determinant, requires input from multiple processes including endocytosis and recycling. In metazoan cells, Cdc42 can regulate several steps in the biosynthetic as well as endocytotic and recycling pathways. The recent discovery that the Par polarity complex co-operates with Cdc42 in the regulation of endocytosis and recycling opens exciting possibilities for the integration of polarity protein function and endocytotic machinery.Keywords
This publication has 72 references indexed in Scilit:
- Polarized traffic towards the cell surface: how to find the routeBiology of the Cell, 2010
- Apical trafficking in epithelial cells: signals, clusters and motorsJournal of Cell Science, 2009
- Pathways and mechanisms of endocytic recyclingNature Reviews Molecular Cell Biology, 2009
- Endocytosis and signalling: intertwining molecular networksNature Reviews Molecular Cell Biology, 2009
- New roles for endosomes: from vesicular carriers to multi-purpose platformsNature Reviews Molecular Cell Biology, 2009
- Coordinated protein sorting, targeting and distribution in polarized cellsNature Reviews Molecular Cell Biology, 2008
- Chapter 4 Protein Trafficking in Polarized CellsPublished by Elsevier BV ,2008
- The PAR Proteins: Fundamental Players in Animal Cell PolarizationDevelopmental Cell, 2007
- Adaptation of core mechanisms to generate cell polarityNature, 2003
- Composition and Formation of Intercellular Junctions in Epithelial CellsScience, 2002