New roles for endosomes: from vesicular carriers to multi-purpose platforms
- 11 March 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 10 (4), 287-292
- https://doi.org/10.1038/nrm2652
Abstract
Endosomes have important roles in processes, including cytokinesis, polarization and migration, in which their function might be distinct from those classically associated with endosomes. We speculate that endosomes function as multifunctional platforms on which unique sets of molecular machines are assembled to suit different cellular roles. The careful sorting and recycling of membranes and cargo and the intracellular delivery of proteins, toxins and viruses by endocytosis are well-established roles for the endocytic apparatus, which is present in all eukaryotic cells. Recently, it has become clear that endosomes have key roles in such diverse processes as cytokinesis, polarization and migration, in which their functions might be distinct from those classically associated with endosomes. We speculate that endosomes function as multifunctional platforms on which unique sets of molecular machines are assembled to suit different cellular roles.Keywords
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