Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms
Top Cited Papers
Open Access
- 1 January 2009
- journal article
- review article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 89 (1), 1-14
- https://doi.org/10.3945/ajcn.2008.26792
Abstract
Nonnutritive sweeteners (NNS) are ecologically novel chemosensory signaling compounds that influence ingestive processes and behavior. Only about 15% of the US population aged >2 y ingest NNS, but the incidence is increasing. These sweeteners have the potential to moderate sugar and energy intakes while maintaining diet palatability, but their use has increased in concert with BMI in the population. This association may be coincidental or causal, and either mode of directionality is plausible. A critical review of the literature suggests that the addition of NNS to non-energy-yielding products may heighten appetite, but this is not observed under the more common condition in which NNS is ingested in conjunction with other energy sources. Substitution of NNS for a nutritive sweetener generally elicits incomplete energy compensation, but evidence of long-term efficacy for weight management is not available. The addition of NNS to diets poses no benefit for weight loss or reduced weight gain without energy restriction. There are long-standing and recent concerns that inclusion of NNS in the diet promotes energy intake and contributes to obesity. Most of the purported mechanisms by which this occurs are not supported by the available evidence, although some warrant further consideration. Resolution of this important issue will require long-term randomized controlled trials.This publication has 152 references indexed in Scilit:
- Relationships between human thirst, hunger, drinking, and feedingPhysiology & Behavior, 2008
- Short-term dietary compensation in free-living adultsPhysiology & Behavior, 2008
- Diverse tastes: Genetics of sweet and bitter perceptionPhysiology & Behavior, 2006
- Physiological mechanisms mediating aspartame-induced satietyPhysiology & Behavior, 2003
- Laboratory hedonic ratings as predictors of consumptionFood Quality and Preference, 1999
- Sensory and Hedonic Judgments of Common Foods by Lean Consumers and Consumers with ObesityObesity Research, 1998
- Cyclamate consumption in Catalonia, Spain (1992): Relationship with the body mass IndexFood Additives & Contaminants, 1996
- Manometric responses of human duodenum during infusion of HCl, hyperosmolar saline, bile and oleic acidNeurogastroenterology & Motility, 1996
- Postingestive inhibition of food intake by aspartame: Importance of interval between aspartame administration and subsequent eatingPhysiology & Behavior, 1995
- Gustatory Sequelae of Alimentary DisordersDigestive Diseases, 1986