Beta Cell Function and Insulin Resistance in Nondiabetic, Prediabetic and Diabetic in a Subset of Obese Pakistani Population
- 22 September 2021
- journal article
- research article
- Published by Sciencedomain International in Journal of Pharmaceutical Research International
- Vol. 33 (44B), 214-219
- https://doi.org/10.9734/jpri/2021/v33i44b32669
Abstract
Objective: To compare insulin resistance and beta-cell function in nondiabetic, prediabetic, and diabetic subjects in a subset of obese Pakistani population. Materials and Methods: Two hundred and ten obese subjects underwent anthropometric measurements. After overnight fasting for 8 hours, 6 cc blood was drawn for fasting blood glucose level, fasting insulin level. Blood glucose samples were taken after drinking 75 gm glucose in 260 ml water. HOMA IR and HOMA BETA% were calculated by the formula. Subjects were divided into obese nondiabetic, obese prediabetic and obese diabetic according to WHO criteria. Results: Out of 210 obese subjects, 53 (25.2%) were males and 157 (74.8%) were females. The mean BMI was 32.39±5.21. Mean abdominal circumference was 102.78±10.16. There were 101(48%) obese nondiabetic, 51(24%) were found to be obese prediabetic, 58(28%) were found to be obese diabetic. Mean insulin resistance in obese nondiabetic subjects was 2.8 ±3.7, in prediabetic 8.5± 12.3, in diabetic was 17.7±24.6. Mean HOMA beta was 245.3±267.4 in obese nondiabetic subjects, 290.5±298.4 in prediabetic, and 16.6±57 in diabetic. Conclusion: There was a significantly increased incidence of prediabetes and diabetes in obese subjects. Prediabetic and diabetic subjects were found to have marked insulin resistance. Beta-cell function was markedly reduced in diabetic subjects having a family history of diabetes, emphasizing the genetic predisposition to develop beta-cell exhaustion.Keywords
This publication has 17 references indexed in Scilit:
- Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderlyAfrican Health Sciences, 2018
- Obesity and inflammation: the linking mechanism and the complicationsVideosurgery and Other Miniinvasive Techniques, 2017
- Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and ChemokinesISRN Inflammation, 2013
- Role of Reduced β-Cell Mass Versus Impaired β-Cell Function in the Pathogenesis of Type 2 DiabetesDiabetes Care, 2013
- Islet β cell mass in diabetes and how it relates to function, birth, and deathAnnals of the New York Academy of Sciences, 2013
- Beta Cell Dysfunction and Insulin ResistanceFrontiers in Endocrinology, 2013
- Inflammation as a Link between Obesity and Metabolic SyndromeJournal of Nutrition and Metabolism, 2012
- Diabetes Mellitus and the β Cell: The Last Ten YearsCell, 2012
- The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysisThe British Journal of Radiology, 2012
- Preventive pharmacotherapy in type 2 diabetes mellitusIndian Journal of Endocrinology and Metabolism, 2012