Beta Cell Dysfunction and Insulin Resistance
Top Cited Papers
Open Access
- 1 January 2013
- journal article
- Published by Frontiers Media SA in Frontiers in Endocrinology
- Vol. 4, 37
- https://doi.org/10.3389/fendo.2013.00037
Abstract
Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states induce hyperglycemia and therefore increase insulin demand. Beta cell dysfunction results from inadequate glucose sensing to stimulate insulin secretion therefore elevated glucose concentrations prevail. Persistently elevated glucose concentrations above the physiological range result in the manifestation of hyperglycemia. With systemic insulin resistance, insulin signaling within glucose recipient tissues is defective therefore hyperglycemia perseveres. Beta cell dysfunction supersedes insulin resistance in inducing diabetes. Both pathological states influence each other and presumably synergistically exacerbate diabetes. Preserving beta cell function and insulin signaling in beta cells and insulin signaling in the glucose recipient tissues will maintain glucose homeostasis.Keywords
This publication has 102 references indexed in Scilit:
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskNature Genetics, 2010
- Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory GranulesCell Metabolism, 2009
- Pdx1 ( MODY4 ) regulates pancreatic beta cell susceptibility to ER stressProceedings of the National Academy of Sciences of the United States of America, 2009
- Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell functionHuman Molecular Genetics, 2009
- Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiationDevelopmental Biology, 2008
- Recovery from diabetes in mice by β cell regenerationJCI Insight, 2007
- Insulin receptors in β-cells are critical for islet compensatory growth response to insulin resistanceProceedings of the National Academy of Sciences of the United States of America, 2007
- Human Islet Oxygen Consumption Rate and DNA Measurements Predict Diabetes Reversal in Nude MiceAmerican Journal of Transplantation, 2007
- PPARs, Obesity, and InflammationPPAR Research, 2006
- Inflammation and insulin resistanceJCI Insight, 2006