Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly
Open Access
- 4 April 2018
- journal article
- research article
- Published by African Journals Online (AJOL) in African Health Sciences
- Vol. 18 (1), 120-131
- https://doi.org/10.4314/ahs.v18i1.16
Abstract
Background: Aging is characterized with immunosenescence associated with a hyper-inflammatory state, characterized by elevated circulating levels of pro-inflammatory mediators. Physical exercise is a potential strategy for improving the immune system dysfunction and chronic inflammation that accompanies aging. However, there is a need to differentiate between aerobic and resistance exercise training regarding human immune system and systemic inflammation among the elderly Saudi population. Objective: The aim of this study was to compare the impact of 6 months of aerobic versus resisted exercise training on inflammatory cytokines and immune system response among elderly. Material and methods: Sixty previously sedentary elderly subjects participated in this study, their age ranged from 61- 66 years. All Subjects were randomly assigned to supervised aerobic exercise intervention group (group A, n=40) or resistance exercise group (group B, n=40). Number of CD3+,CD4+,CD8+ T cells count and CD4/CD8 ratio were quantified, IL-6, TNF-α and IL10 were measured before and after 6 months, at the end of the study. Results: The mean values of CD3+, CD4+ and CD8+ T cells count and IL-10 were significantly increased, whereas the mean values of CD4/CD8 ratio,IL-6 and TNF-α were significantly decreased in group (A) and group (B). Also; there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment. Conclusion: The current study provides evidence that aerobic exercise is more appropriate in modulating the immune system and inflammatory markers among the elderly population. Keywords: Immune function, inflammatory cytokines, aerobic exercise, resistance exercise, aging.Keywords
This publication has 54 references indexed in Scilit:
- Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal womenJournal of Sports Sciences, 2009
- Associations of Physical Activity With Inflammatory Factors, Adipocytokines, and Metabolic Syndrome in Middle-Aged and Older Chinese PeopleCirculation, 2009
- Exercise Training and Plasma C‐Reactive Protein and Interleukin‐6 in Elderly PeopleJournal of the American Geriatrics Society, 2008
- Exercise as a Mean to Control Low-Grade Systemic InflammationMediators of Inflammation, 2008
- Cytokine responses to resistance training in people with multiple sclerosisJournal of Sports Sciences, 2006
- Immune activation is associated with reduced skeletal muscle mass and physical function in chronic heart failureInternational Journal of Cardiology, 2006
- Oxidative StressSports Medicine, 2006
- Physical activity and modulation of systemic low-level inflammationJournal of Leukocyte Biology, 2005
- Strength, workload, anaerobic intensity and the immune response to resistance exercise in womenActa Physiologica Scandinavica, 2003
- Effects of exercise on the immune system in the elderly populationImmunology & Cell Biology, 2000