Deregulation of Interleukin-2 Receptor Gene Expression in HTLV-I-Induced Adult T-Cell Leukemia
- 7 June 1985
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 228 (4704), 1215-1217
- https://doi.org/10.1126/science.2988127
Abstract
Infection of human T cells by human T-lymphotropic virus, type I (HTLV-I), a retrovirus, is uniformly associated with the constitutive expression of large numbers of cellular receptors for interleukin-2 (IL-2). Comparison with normal T cells shows that neither IL-2 receptor gene organization nor IL-2 receptor messenger RNA processing are altered in the leukemic cells. However, mitogenic stimuli activate IL-2 receptor gene expression in normal T cells, whereas these stimuli paradoxically inhibit IL-2 receptor gene transcription in HTLV-I-infected leukemic T cells.Keywords
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