Molecular cloning of cDNA encoding human interleukin-2 receptor
- 1 October 1984
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 311 (5987), 631-635
- https://doi.org/10.1038/311631a0
Abstract
The human interleukin-2 (IL-2) receptor was purified by affinity chromatography using the anti-Tac monoclonal antibody, and its N-terminal amino acid sequence was determined. Complementary DNA clones were isolated and sequenced to reveal the primary structure of the IL-2 receptor precursor, which has 272 amino acid residues. The receptor is separated into two domains by a putative 19-residue transmembrane region. Two mRNAs (1.4 and 3.5 kilobases) hybridizing to the cDNA clone were found in human T cells bearing the IL-2 receptor. The cDNA directed synthesis of the IL-2 receptor in COS cells.This publication has 42 references indexed in Scilit:
- Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequencesNature, 1984
- Transient expression of interleukin 2 receptors. Consequences for T cell growth.The Journal of Experimental Medicine, 1983
- Direct demonstration of the identity of T cell growth factor binding protein and the Tac antigen.The Journal of Experimental Medicine, 1983
- A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptorNature, 1982
- T cell growth factor receptors. Quantitation, specificity, and biological relevanceThe Journal of Experimental Medicine, 1981
- SV40-transformed simian cells support the replication of early SV40 mutantsCell, 1981
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980
- Cloning and complete nucleotide sequence of mouse immunoglobulin γ1 chain geneCell, 1979
- Selective in Vitro Growth of T Lymphocytes from Normal Human Bone MarrowsScience, 1976
- Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology, 1975