Helicobacter pylori Virulence and Genetic Geography
- 21 May 1999
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 284 (5418), 1328-1333
- https://doi.org/10.1126/science.284.5418.1328
Abstract
Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.This publication has 87 references indexed in Scilit:
- Type III Secretion Machines: Bacterial Devices for Protein Delivery into Host CellsScience, 1999
- Helicobacter pyloriamong Preschool Children and Their Parents: Evidence of Parent‐Child TransmissionThe Journal of Infectious Diseases, 1999
- Three-Dimensional Reconstruction of Metal Replicas of theHelicobacter pyloriVacuolating CytotoxinJournal of Structural Biology, 1998
- Who Speaks for the Microbes?Emerging Infectious Diseases, 1998
- How is the intracellular fate of the Legionella pneumophila phagosome determined?Trends in Microbiology, 1998
- Infection withHelicobacter pyloriExpressing thecagAGene Is Not Associated with an Increased Risk of Developing Peptic Ulcer Diseases in Korean PatientsScandinavian Journal of Gastroenterology, 1998
- Vacuolating Toxin Gene Polymorphism amongHelicobacter pyloriClinical Isolates and Its Association with m1, m2, or ChimericvacAMiddle TypesScandinavian Journal of Gastroenterology, 1998
- Prospects for the Development of a Vaccine Against Helicobacter pyloriDrugs, 1996
- Heterogeneous Helicobacter pylori isolates from members of a family with a history of peptic ulcer diseaseGastroenterology, 1996
- Unravelling the pathogenic role of Helicobacter pylori in peptic ulcer: Potential new therapies and vaccinesTrends in Biotechnology, 1994