How is the intracellular fate of the Legionella pneumophila phagosome determined?
Open Access
- 1 July 1998
- journal article
- review article
- Published by Elsevier BV in Trends in Microbiology
- Vol. 6 (7), 253-255
- https://doi.org/10.1016/s0966-842x(98)01308-0
Abstract
The following pair of articles, the first by Gil Segal and Howard Shuman, and the second by James Kirby and Ralph Isberg (Trends Microbiol. 6, 256-258), explore the genetics and function of the icm/dot genes of Legionella pneumophila. This gene family is implicated in several aspects of virulence and appears to constitute components of a conjugal transfer system that has been adopted to prevent phagosome-lysosome fusion in the host cell and to mediate host cytotoxicity by pore formation. Whether these functions are natural consequences or operate in parallel remains to be discovered.Keywords
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