MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing
Open Access
- 1 January 2021
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Research
- Vol. 2021, 9838490
- https://doi.org/10.34133/2021/9838490
Abstract
Wound healing is a complex physiological process that involves coordinated phases such as inflammation and neovascularization. Attempts to promote the healing process tend to construct an effective delivery system based on different drugs and materials. In this paper, we propose novel MXene-integrated microneedle patches with adenosine encapsulation for wound healing. Owing to the dynamic covalent bonding capacity of boronate molecules with adenosine, 3-(acrylamido)phenylboronic acid- (PBA-) integrated polyethylene glycol diacrylate (PEGDA) hydrogel is utilized as the host material of microneedle patches. Benefitting from photothermal conversion capacity of MXene, the release of loaded adenosine could be accelerated under NIR irradiation for maintaining the activation signal around injury site. In vitro cell experiments proved the effect of MXene-integrated microneedle patches with adenosine encapsulation in enhancing angiogenesis. When applied for treating animal models, it is demonstrated that the microneedle patches efficiently promote angiogenesis, which is conductive to wound healing. These features make the proposed microneedle patch potential for finding applications in wound healing and other biomedical fields.Keywords
Funding Information
- Shenzhen Fundamental Research Program (JCYJ20190813152616459)
- Natural Science Foundation of Jiangsu Province (BE2018707)
- National Natural Science Foundation of China (61927805, 52073060)
- National Key Research and Development Program of China (2020YFA0908200)
This publication has 40 references indexed in Scilit:
- Surface Modified Ti3C2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic TherapyACS Applied Materials & Interfaces, 2017
- Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure TheranosticsAdvanced Materials, 2017
- Cell volume change through water efflux impacts cell stiffness and stem cell fateProceedings of the National Academy of Sciences of the United States of America, 2017
- Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO NanostructuresACS Nano, 2017
- Advances in engineering hydrogelsScience, 2017
- Synthesis and Applications of Boronic Acid-Containing Polymers: From Materials to MedicineChemical Reviews, 2015
- Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocksNature Materials, 2015
- Wound repair and regeneration: Mechanisms, signaling, and translationScience Translational Medicine, 2014
- A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissueNature Communications, 2013
- Adenosine Promotes Wound Healing and Mediates Angiogenesis in Response to Tissue Injury Via Occupancy of A2A ReceptorsThe American Journal of Pathology, 2002