Surface Modified Ti3C2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic Therapy
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- 9 November 2017
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Applied Materials & Interfaces
- Vol. 9 (46), 40077-40086
- https://doi.org/10.1021/acsami.7b13421
Abstract
Ti3C2 MXene is a new two-dimensional material exhibiting a variety of novel properties including good photothermal effect, and the capability of Ti3C2 for multimodal tumor therapy is in urgent need of development. Herein, ultrathin Ti3C2 MXene nanosheets (∼100 nm) have been synthesized by supplying additive Al3+ to avoid Al loss and employed as a photothermal/photodynamic agent for cancer therapy. The as-obtained nanosheets exhibit outstanding mass extinction coefficient (28.6 Lg–1 cm–1 at 808 nm), superior photothermal conversion efficiency (∼58.3%), and effective singlet oxygen generation (1O2) upon 808 nm laser irradiation. Based on these Ti3C2 nanosheets, a multifunctional nanoplatform (Ti3C2-DOX) is established via layer-by-layer surface modification with doxorubicin (DOX) and hyaluronic acid (HA). In vitro and in vivo experiments disclose that Ti3C2-DOX shows enhanced biocompatibility, tumor specific accumulation, and stimuli-responsive drug release behavior and achieve effective cancer cell killing and tumor tissue destruction through photothermal/photodynamic/chemo synergistic therapy.Keywords
Funding Information
- Natural Science Foundation of Jiangsu Province (BK20161012)
- National Natural Science Foundation of China (61525402, 61604071, 61775095)
- Jiangsu Province (15KJA430006, BE2017741)
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