Insights into the Links between MYC and 3D Chromatin Structure and Epigenetics Regulation: Implications for Cancer Therapy
- 20 January 2021
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 81 (8), 1925-1936
- https://doi.org/10.1158/0008-5472.can-20-3613
Abstract
MYC is embedded in the transcriptional oasis of the 8q24 gene desert. A plethora of genomic elements participate in the aberrant expression of MYC in cancer development by interacting with transcription factors and epigenetic regulators as well as by altering the structure of chromatin at the MYC locus and tissue-specific long-range enhancer-promoter contacts. MYC is a master regulator of several human cancers, often modulating the transcription of numerous cancer-related genes through epigenetic mechanisms. This review provides a comprehensive overview of the three-dimensional genomic organization around MYC, the role of epigenetic machinery in transcription and function of MYC, and the various epigenetic-targeted therapeutic strategies in MYC-driven cancers.Other Versions
Funding Information
- Babol University of Medical Sciences
This publication has 175 references indexed in Scilit:
- MYC on the Path to CancerCell, 2012
- Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin InteractionsMolecular Cell, 2011
- H3K4 tri-methylation provides an epigenetic signature of active enhancersThe EMBO Journal, 2011
- Selective inhibition of BET bromodomainsNature, 2010
- Identification of a new prostate cancer susceptibility locus on chromosome 8q24Nature Genetics, 2009
- The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancerNature Genetics, 2009
- The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene ExpressionJournal of Medicinal Chemistry, 2009
- Genome-wide association study identifies novel breast cancer susceptibility lociNature, 2007
- Multiple regions within 8q24 independently affect risk for prostate cancerNature Genetics, 2007
- The great MYC escape in tumorigenesisCancer Cell, 2005