Schematic model for MYC-mediated transcription regulation. MYC potentially regulates the expression of a variety of genes involved in cell growth, apoptosis, proliferation, and immortalization by recruiting a large number of proteins. MYC interacts with two major protein complexes including HATs with GCN5, and Tip60 for ATP-dependent chromatin remodeling. HAT: histone acetyl-transferases; MAX: MYC associated factor X; Tip60: tat interactive protein 60; P300/CBP: p300/CREB-binding protein; GCN5: Gcn5-related N-acetyltransferase: SWI/SNF: SWItch/sucrose non-fermentable SWI/SNF.