Chemical Constituents of a Marine Fungus, Arthrinium sacchari
- 30 June 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 74 (7), 1645-1649
- https://doi.org/10.1021/np200108h
Abstract
Three new diterpenes, myrocin D (1), libertellenone E (2), and libertellenone F (3), and a new isocoumarin, decarboxyhydroxycitrinone (4), were isolated from the marine fungus Arthrinium sacchari, together with three known compounds (5–7). The structures of 1–4 were elucidated from spectroscopic data (NMR, MS, IR), and the absolute configurations of 1–3 were determined by X-ray diffraction analysis. The antiangiogenic activity of these compounds was evaluated by measuring their antiproliferation effects on human umbilical vein endothelial cells (HUVECs) and human umbilical artery endothelial cells (HUAECs). Compounds 4–7 showed inhibitory activity.Keywords
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